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764736

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average Mn 2,000, PDLLA average Mn 2,000

Synonyme(s) :

PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA

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About This Item

Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

pellets

Niveau de qualité

100

Poids mol.

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

Intervalle de dégradation

2-5 weeks

Température de transition

Tm 29-33 °C

PDI

<1.1 (typical PEG)
<1.2
<1.3 (overall)

Température de stockage

2-8°C

Catégories apparentées

Description générale

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

Application

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

Caractéristiques et avantages

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

>230.0 °F

Point d'éclair (°C)

> 110 °C

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Certificats d'analyse (COA)

Lot/Batch Number
MKBZ8548V
MKBX7526V
MKBP5197V

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Consulter la Bibliothèque de documents

Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

Articles

Solubility enhancement of hydrophobic drugs via drug-loaded micelles using biodegradable PEG- polyester diblock copolymers

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded micelles.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation

Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a given time period.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

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