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Key Documents

Autres documents

284335

Sigma-Aldrich

1,3-Dinitropyrene

99%

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About This Item

Formule empirique (notation de Hill):
C16H8N2O4
Numéro CAS:
75321-20-9
Poids moléculaire :
292.25
Numéro MDL:
MFCD00010493
Code UNSPSC :
12352100
ID de substance PubChem :
24857149
Nomenclature NACRES :
NA.22

Pureté

99%

Forme

solid

Solubilité

DMSO: soluble 2 mg/mL, clear, yellow to orange

Chaîne SMILES 

[O-][N+](=O)c1cc([N+]([O-])=O)c2ccc3cccc4ccc1c2c34

InChI

1S/C16H8N2O4/c19-17(20)13-8-14(18(21)22)12-7-5-10-3-1-2-9-4-6-11(13)16(12)15(9)10/h1-8H

Clé InChI

KTNUVDBUEAQUON-UHFFFAOYSA-N

Catégories apparentées

Description générale

The carcinogenecity of 1,3-dinitropyrene was studied in newborn female rats.

Application

1,3-Dinitropyrene has been used in:
  • modification of the umu-assay (ISO 13829) to assess the cytotoxic potential of toxins
  • in vitro synthesis of 1,N6-etheno-2′-deoxyadenosine and 1,N2-etheno-2′-deoxyguanosine

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H312 + H332

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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L B Tee et al.
Carcinogenesis, 9(10), 1869-1874 (1988-10-01)
Dinitropyrenes are mutagenic and carcinogenic environmental pollutants commonly found in diesel exhaust and airborne particulates. In the present study, the ability of rabbit lung to metabolize 1,8-dinitro[4,5,9,10-3H]pyrene by both oxygen-dependent and oxygen-independent pathways has been investigated. Using lung 9000 g
H Lee et al.
Mutation research, 324(1-2), 77-84 (1994-06-01)
The disposal of massive quantities of synthetic materials has become a very serious environmental problem around the world. When synthetic polymers are burnt or smolder in air, the combustion products are extremely complex, often consisting of several hundred compounds. In
A K Hajos et al.
Journal of biochemical toxicology, 6(4), 277-282 (1991-01-01)
The effect of highly purified rat liver cytosolic NAD(P)H-quinone oxidoreductase [EC 1.6.99.2] on the mutagenicity of 1,3- 1,6- and 1,8-dinitropyrene (DNP) was studied in the Ames Salmonella typhimurium mutagenicity assay. NAD(P)H-quinone oxidoreductase over the range of 0.02-0.8 micrograms/plate (38-1500) units
G W Winston et al.
Mutation research, 279(4), 289-298 (1992-06-16)
The effects of chronic ethanol feeding of rats on the ability of liver fractions to modulate the bacterial mutagenicity of three dinitropyrene isomers (1,3-, 1,6- and 1,8-DNP), which require bacterial enzymes but not an exogenous enzyme source for activation, were
C A Norman et al.
Carcinogenesis, 10(7), 1323-1327 (1989-07-01)
Formation of DNA adducts, following treatment of primary rabbit tracheal epithelial cells (RTEC) with 1,8-dinitropyrene (1,8-DNP) and its partially reduced derivative, 1-nitro-8-nitrosopyrene (1,8-NONO2), was examined using the 32P-post-labelling technique. Treatment of aerobic cells with 1,8-DNP or 1,8-NONO2 produced qualitatively similar
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