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Key Documents

102601

Sigma-Aldrich

3,4-Dihydroxyhydrocinnamic acid

98%

Synonyme(s) :

3-(3,4-Dihydroxyphenyl)propionic acid, Hydrocaffeic acid

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About This Item

Formule linéaire :
(HO)2C6H3CH2CH2CO2H
Numéro CAS:
Poids moléculaire :
182.17
Numéro Beilstein :
2213449
Numéro CE :
Numéro MDL:
Code UNSPSC :
12162002
ID de substance PubChem :
Nomenclature NACRES :
NA.23

Pureté

98%

Pf

136-139 °C (lit.)

Chaîne SMILES 

OC(=O)CCc1ccc(O)c(O)c1

InChI

1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)

Clé InChI

DZAUWHJDUNRCTF-UHFFFAOYSA-N

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Description générale

3,4-Dihydroxyhydrocinnamic acid (DHCA) belongs to the class of monomers known as hydroxycinnamic acids. DHCA, also known as hydrocaffeic acid, can be polymerized to form various caffeic acid-based polymers. These polymers can be used in the development of coatings, films, and packaging materials due to their antioxidant and antimicrobial properties. caffeic acid-based polymers have also shown potential applications in drug delivery systems, tissue engineering, and encapsulation of bioactive compounds. Additionally, these polymers can be incorporated into cosmetic and personal care products due to their antioxidant and anti-inflammatory properties.

Application

3,4-Dihydroxyhydrocinnamic acid(DHCA) can be used as a monomer to prepare muscle-mimetic, bioadhesive polymers. The strong adhesive action of the polymers is due to interactions of catechol groups present at the end of the polymer terminal chain and substrate surface.
It can also be used for thesurface functionalization of nanoparticles. The functionalization with DHCA notonly improves the water solubility of nanoparticles but also provides a platformfor further modification due to the presence of surface carboxyl groups.

Pictogrammes

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Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Kebba Sabally et al.
Journal of biotechnology, 127(1), 167-176 (2006-08-15)
Lipase-catalyzed transesterification reaction of dihydrocaffeic acid (DHCA) with flaxseed oil in organic solvent media was investigated. Using equal molar concentration of DHCA and flaxseed oil, only phenolic monoacylglycerols were obtained with a transesterification yield (TY) of 18.9%. A 1:4 DHCA
Reina Aoki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16603-16610 (2011-11-18)
The ability to detect harmful chemicals rapidly is essential for the survival of all animals. In Caenorhabditis elegans (C. elegans), repellents trigger an avoidance response, causing animals to move away from repellents. Dihydrocaffeic acid (DHCA) is a water-soluble repellent and
Charlotte S Hunneche et al.
Journal of agricultural and food chemistry, 56(19), 9258-9268 (2008-09-12)
A combinatorial chemistry approach was employed for the design and systematic synthesis of antioxidant-emulsifier bioconjugates to improve antioxidant activity in the interface between oil and water. A combinatorial library of 12 bioconjugates was synthesized from the phenolic antioxidants Trolox (a
Lee E Hunt et al.
Biomolecules, 11(1) (2021-01-06)
There is ongoing interest in exploiting the antioxidant activity and other medicinal properties of natural monophenolic/polyphenolic compounds, but their generally low aqueous solubility limits their applications. Numerous studies have been undertaken to solubilize such compounds via supramolecular derivatization with co-crystal
María Monagas et al.
The British journal of nutrition, 102(2), 201-206 (2009-07-10)
Oligomers and polymers of flavan-3-ols (proanthocyanidins) are very abundant in the Mediterranean diet, but are poorly absorbed. However, when these polyphenols reach the colon, they are metabolised by the intestinal microbiota into various phenolic acids, including phenylpropionic, phenylacetic and benzoic

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