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Key Documents

1.05104

Supelco

Potassium phosphate dibasic

anhydrous for analysis EMSURE®

Synonym(s):

Potassium phosphate dibasic, Dipotassium hydrogen phosphate, Potassium phosphate dibasic, Dipotassium Phosphate, di-Potassium hydrogen phosphate, Dipotassium hydrogenphosphate, Dipotassium phosphate, sec.-Potassium phosphate

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About This Item

Linear Formula:
K2HPO4
CAS Number:
Molecular Weight:
174.18
MDL number:
UNSPSC Code:
12352302
EC Index Number:
231-834-5
NACRES:
NA.21

Quality Level

product line

EMSURE®

Assay

≥99.0% (alkalimetric)

form

solid

potency

8000 mg/kg LD50, oral (Rat)

loss

≤1% loss on drying, 130 °C

pH

9 (20 °C, 10 g/L in H2O)

solubility

1600 g/L

density

2.44 g/cm3 at 20 °C

bulk density

700‑1000 kg/m3

anion traces

chloride (Cl-): ≤0.003%
sulfate (SO42-): ≤0.005%

cation traces

Fe: ≤0.0010%
N: ≤0.001%
Na: ≤0.5%
heavy metals (as Pb): ≤0.0005%

storage temp.

15-25°C

SMILES string

[K+].[K+].OP([O-])([O-])=O

InChI

1S/2K.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2

InChI key

ZPWVASYFFYYZEW-UHFFFAOYSA-L

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Application


  • Bromination of aromatic compounds by residual bromide in sodium chloride matrix modifier salt during heated headspace GC/MS analysis.: This research investigates the role of potassium phosphate dibasic in the bromination of aromatic compounds, providing insights into its application in GC/MS analysis (Fine et al., 2013).

  • Purification of porcine pancreatic lipase by aqueous two-phase systems of polyethylene glycol and potassium phosphate.: The study details the use of potassium phosphate dibasic in the purification of porcine pancreatic lipase using an aqueous two-phase system, demonstrating its utility in biochemical separation processes (Zhou et al., 2013).

  • Cloning, purification, crystallization and preliminary X-ray crystallographic analysis of a cyclophilin A-like protein from Piriformospora indica.: This article discusses the use of potassium phosphate dibasic in the crystallization process of a cyclophilin A-like protein, contributing to structural biology research (Bhatt et al., 2012).

  • A validated enantioselective HPLC assay of dexibuprofen in dexibuprofen tablet formulations.: Potassium phosphate dibasic is utilized in the development of an enantioselective HPLC assay for dexibuprofen, enhancing pharmaceutical analysis techniques (Awad et al., 2012).

  • Monitoring of phenylurea and propanil herbicides in river water by solid-phase-extraction high performance liquid chromatography with photoinduced-fluorimetric detection.: The study employs potassium phosphate dibasic in the analysis of herbicides in river water, demonstrating its application in environmental monitoring and water quality assessment (de la Peña et al., 2003).

Analysis Note

Assay (alkalimetric): ≥ 99.0 %
pH-value (5 %; water): 8.7 - 9.3
Chloride (Cl): ≤ 0.003 %
Sulfate (SO₄): ≤ 0.005 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (as Pb): ≤ 0.0005 %
Fe (Iron): ≤ 0.0010 %
Na (Sodium): ≤ 0.5 %
Loss on drying (130 °C): ≤ 1.0 %

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Protocols

This paper illustrates the setting up of a Lopinavir assay following European pharmacopoeia guidelines (10.2), and using a shorter column packed with smaller particles. The described assay saves valuable time and improves separation efficiency, which typically translates to better method performance.

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