Skip to Content
Merck
All Photos(2)

Key Documents

1.04873

Supelco

Potassium phosphate monobasic

for analysis EMSURE® ISO

Synonym(s):

Potassium phosphate monobasic, Potassium dihydrogen phosphate, mono-Potassium orthophosphate, Potassium biphosphate, Potassium phosphate monobasic, Monopotassium phosphate, prim.-Potassium phosphate

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
KH2PO4
CAS Number:
Molecular Weight:
136.09
MDL number:
UNSPSC Code:
12352302
EC Index Number:
231-913-4
NACRES:
NA.21

Agency

reag. ISO
suitable for SM 5210

Quality Level

product line

EMSURE®

Assay

≥99.5% dry basis (alkalimetric)
99.5-100.5% (alkalimetric)

form

solid

potency

>4640 mg/kg LD50, skin (Rabbit)

technique(s)

UV/Vis spectroscopy: suitable

loss

≤0.2% loss on drying, 110 °C
≤0.2% loss on drying, 130 °C

pH

4.2-4.6 (20 °C, 20 g/L in H2O)

mp

252.6 °C (lit.)

solubility

208 g/L

density

2.338 g/mL at 25 °C (lit.)

bulk density

1200 kg/m3

anion traces

chloride (Cl-): ≤0.0005%
sulfate (SO42-): ≤0.003%

cation traces

As: ≤0.0002%
Cu: ≤0.0003%
Fe: ≤0.0010%
N: ≤0.001%
Na: ≤0.02%
Pb: ≤0.001%
heavy metals (as Pb): ≤0.0010%

storage temp.

2-30°C

SMILES string

[K+].OP(O)([O-])=O

InChI

1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1

InChI key

GNSKLFRGEWLPPA-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

Application


  • β-lactoglobulin stabilized nanemulsions--Formulation and process factors affecting droplet size and nanoemulsion stability.: This research explores the stabilization mechanisms of β-lactoglobulin in nanemulsions, with implications for pharmaceutical and food sciences, potentially utilizing substances like potassium phosphate monobasic for stability and pH control (Ali et al., 2016).

  • Reverse phase liquid chromatographic determination of sulfathiazole residues in honey.: Discusses a method for detecting sulfathiazole in honey using reverse-phase liquid chromatography, highlighting the importance of analytical techniques that could involve reagents like potassium phosphate monobasic for sample preparation and analysis (Barry and MacEachern, 1983).


Analysis Note

Assay (alkalimetric, calculated on dried substance): 99.5 - 100.5 %
Assay (alkalimetric; dried substance): ≥ 99.5 %
pH-value (5 %; water): 4.2 - 4.5
Chloride (Cl): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.003 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (as Pb): ≤ 0.0010 %
As (Arsenic): ≤ 0.0002 %
Cu (Copper): ≤ 0.0003 %
Fe (Iron): ≤ 0.0010 %
Na (Sodium): ≤ 0.02 %
Pb (Lead): ≤ 0.001 %
Reducing substances: passes test
Loss on drying (110 °C): ≤ 0.2 %
Loss on drying (130 °C): ≤ 0.2 %
Correspons to ISO

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Apixaban is sold under the tradename Eliquis and at present no pharmacopeial monographs are available for Axpixaban using either an assay and/or organic impurity profiling method. A newly developed and validated HPLC-UV method using a column with C18 solid core particles is demonstrated.

Application Note: Peroxidase in vegetables – Visual determination after conversion of a specific substrate.

Following the new USP monograph for Famciclovir Tablets, Purospher™ STAR RP-8 endcapped HPLC columns can be used to monitor organic impurities in Famciclovir tablet formulations. Famciclovir is an antiviral drug indicated for the treatment of herpes zoster, herpes simplex virus 2 (genital herpes), herpes labialis (cold sores), etc.

Protocols

This paper illustrates the setting up of a Lopinavir assay following European pharmacopoeia guidelines (10.2), and using a shorter column packed with smaller particles. The described assay saves valuable time and improves separation efficiency, which typically translates to better method performance.

A complete SEC-UV workflow for quantifying monoclonal antibody fragments, monomers, and aggregates, including procedure for a system suitability test and heat stressing of antibodies.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service