The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

Nature communications (2016-11-25)

Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann

PMID27882935

ZUSAMMENFASSUNG

Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

H3149

Sigma-Aldrich

Heparin Natriumsalz aus Schweinedarm, Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture

F8630

Sigma-Aldrich

Fibrinogen aus Rinderplasma, Type I-S, 65-85% protein (≥75% of protein is clottable)

EHU058661

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO2

EHU076591

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO1

EHU146321

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO4

EHU124361

Sigma-Aldrich

MISSION^® esiRNA, targeting human UNC5B