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Z2626
Zaragozic acid A trisodium salt
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
Synonym(e):
L-694,599, Squalestatin
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About This Item
Empirische Formel (Hill-System):
C35H43O14Na3
CAS-Nummer:
Molekulargewicht:
756.68
MDL-Nummer:
UNSPSC-Code:
12352106
NACRES:
NA.77
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Produktbezeichnung
Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
Biologische Quelle
microbial
Qualitätsniveau
Assay
≥95% (HPLC)
Form
lyophilized powder
Löslichkeit
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Versandbedingung
wet ice
Lagertemp.
−20°C
Anwendung
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Biochem./physiol. Wirkung
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Rechtliche Hinweise
Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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