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V5765
Vascular Endothelial Growth Factor 165 human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.77
Empfohlene Produkte
Produktbezeichnung
VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in HEK 293 cells
Beschreibung
Vascular Endothelial Growth Factor 165 human
Assay
≥95% (SDS-PAGE)
Form
lyophilized powder
Wirksamkeit
<10 ng/mL ED50
Qualität
endotoxin tested
Mol-Gew.
dimer 42 kDa (glycosylated)
Verpackung
pkg of 10 μg
pkg of 50 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<0.075 EU/μg
Farbe
white
Löslichkeit
water: soluble
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... VEGFA(7422)
Allgemeine Beschreibung
VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Biochem./physiol. Wirkung
VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
Hinweis zur Analyse
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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