U6883

cis-Urocanic acid

≥98% (HPLC), solid (fluffy)

• Synonym(e): cis-3-(1H-imidazol-4-yl)-2-propenoic acid, cis-UCA
• Empirische Formel (Hill-System): C₆H₆N₂O₂
• CAS-Nummer: 7699-35-6
• Molekulargewicht: 138.12
• MDL-Nummer: MFCD11045310
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 329827646
• NACRES: NA.77

Eigenschaften

• product name: cis-Urocanic acid, ≥98% (HPLC), solid (fluffy)
• Assay: ≥98% (HPLC)
• Form: solid (fluffy)
• Lagerbedingungen: protect from light
• Farbe: white
• Löslichkeit: H₂O: >10 mg/mL
• Lagertemp.: −20°C
• SMILES String: OC(=O)\C=C/c1c[nH]cn1
• InChI: 1S/C6H6N2O2/c9-6(10)2-1-5-3-7-4-8-5/h1-4H,(H,7,8)(H,9,10)/b2-1-
• InChIKey: LOIYMIARKYCTBW-UPHRSURJSA-N

Beschreibung

Anwendung

cis-Urocanic acid (cis-UCA) has been used:

• to study its protective effects on autoimmune encephalomyelitis
• in sample preparation to study the distribution of skin chemical components by line illumination Raman microscopy technique in Line-focus illumination mode
• as a standard to study the levels of cis-UCA and to check its effect on immune response in multiple sclerosis patients

Biochem./physiol. Wirkung

cis-Urocanic acid (cis-UCA) affects the immune cells of the body and is excreted in the urine due to photoisomerization. It inhibits tumor immunity through photocarcinogenesis in mice. cis-Urocanic acid has been studied to prevent UV-radiation-induced DNA damage leading to skin cancer.

cis-Urocanic acid, a 5-HT agonist, is a product of UV isomerization of trans-urocanic acid in skin, which leads to immunosuppression via activation of 5-HT_2A receptor.

Angaben zur Herstellung

cis-Urocanic acid is soluble in water at a concentration that is greater than 10 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)