T7455

Tolvaptan

≥98% (HPLC), powder

• Synonym(e): N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide, OPC 41061
• Empirische Formel (Hill-System): C₂₆H₂₅ClN₂O₃
• CAS-Nummer: 150683-30-0
• Molekulargewicht: 448.94
• MDL-Nummer: MFCD09838782
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329826866
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: ≥15 mg/mL
• Ersteller: Sanofi Aventis
• Lagertemp.: 2-8°C
• SMILES String: Cc1ccccc1C(=O)Nc2ccc(c(C)c2)C(=O)N3CCCC(O)c4cc(Cl)ccc34
• InChI: 1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
• InChIKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N
• Angaben zum Gen: human ... AVPR2(554)

Beschreibung

Anwendung

Tolvaptan has been used as a V2-selective antagonist for studying its effect on hypertension in mice.

Biochem./physiol. Wirkung

Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.

Tolvaptan is a potent, orally active non-peptide vasopressin V2 receptor antagonist.

Leistungsmerkmale und Vorteile

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Tolvaptan is soluble in DMSO at a concentration that is greater than or equal to 15 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable