T5575

TG003

≥98% (HPLC)

• Synonym(e): (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
• Empirische Formel (Hill-System): C₁₃H₁₅NO₂S
• CAS-Nummer: 300801-52-9
• Molekulargewicht: 249.33
• MDL-Nummer: MFCD00624584
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278611
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• mp (Schmelzpunkt): 132-132.5 °C
• Löslichkeit: DMSO: 33 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
• InChI: 1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
• InChIKey: BGVLELSCIHASRV-QPEQYQDCSA-N

Beschreibung

Anwendung

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

TG003 has been used to develop assays for screening substances that affect mRNA splicing¹.

Biochem./physiol. Wirkung

TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). K_i = 10 nM for mClk1/Sty; IC₅₀ = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.

Verpackung

Packaged under nitrogen.

Angaben zur Herstellung

TG003 is soluble in DMSO at 33 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves