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T4264

Sigma-Aldrich

Tetrahydrozolin -hydrochlorid

≥98% (HPLC)

Synonym(e):

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalinyl)-1H-imidazol -monohydrochlorid, Tetryzolin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C13H16N2 · HCl
CAS-Nummer:
522-48-5
Molekulargewicht:
236.74
EG-Nummer:
208-329-3
MDL-Nummer:
MFCD00058029
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278736
NACRES:
NA.77

Assay

≥98% (HPLC)

Löslichkeit

H2O: freely soluble
alcohol: freely soluble
chloroform: very slightly soluble
diethyl ether: insoluble

Ersteller

Novartis

SMILES String

Cl.C1CC(C2=NCCN2)c3ccccc3C1

InChI

1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

InChIKey

BJORNXNYWNIWEY-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem./physiol. Wirkung

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative. It plays a crucial role in the constriction of conjunctival blood vessels. Tetrahydrozoline is a common component of nasal and eye drop formulations.

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Jennifer A Lowry et al.
Clinical toxicology (Philadelphia, Pa.), 49(5), 434-435 (2011-07-12)
Major symptoms can occur from tetrahydrozoline (THZ) overdoses in young children, requiring intensive care management. We report three cases that presented with CNS depression and cardiovascular effects where serum concentrations were performed. Case 1 ingested an unknown amount of eye
R R Ruffolo et al.
British journal of pharmacology, 77(1), 169-176 (1982-09-01)
1 Noradrenaline and a series of imidazolines were used to characterized and differentiate the postsynaptic alpha-adrenoceptors of rat and rabbit aortae. 2 Dose-response curves in each tissue revealed marked differences in the profile of agonist activity among the compounds. Based
Jason J Nichols et al.
Eye & contact lens, 38(2), 73-79 (2011-12-14)
The purpose of this pilot study was to evaluate the safety and efficacy of azithromycin ophthalmic solution 1% in patients with contact lens-related dry eye (CLDE). This was a 4-week, single-center, open-label clinical trial in patients diagnosed with CLDE using
Giuseppina Sandri et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 62(1), 59-69 (2005-09-16)
Aim of the work was to develop mucoadhesive eyedrops containing tetrahydrozoline hydrochloride (TZ), a decongestant drug, and based on a ternary interaction drug-polymer-polymer. The anionic polymers assessed were the anionic hyaluronic acid (HA) and polyacrylic acid (PAA), the cationic chitosan
Henry Spiller et al.
Clinical toxicology (Philadelphia, Pa.), 46(2), 171-172 (2008-02-09)
Tetrahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations. More than 1,600 cases of oral exposures are reported to United States poison centers annually (1,2). Reports of significant toxicity from
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