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T4143

Sigma-Aldrich

Triamteren

≥99%

Synonym(e):

6-Phenyl-2,4,7-pteridintriamin

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About This Item

Empirische Formel (Hill-System):
C12H11N7
CAS-Nummer:
396-01-0
Molekulargewicht:
253.26
EG-Nummer:
206-904-3
MDL-Nummer:
MFCD00006708
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277877
NACRES:
NA.77

Assay

≥99%

Löslichkeit

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble

Ersteller

Wellspring

SMILES String

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

InChIKey

FNYLWPVRPXGIIP-UHFFFAOYSA-N

Angaben zum Gen

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)

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Anwendung

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Biochem./physiol. Wirkung

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Leistungsmerkmale und Vorteile

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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Bumetanid ≥98%

Sigma-Aldrich

B3023

Bumetanid

Balraj S Heran et al.
The Cochrane database of systematic reviews, (1)(1), CD008167-CD008167 (2010-01-22)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 995-1002 (2008-03-07)
The role of breast cancer resistance protein (BCRP/ABCG2) in limiting the brain and testis penetration of xenobiotic compounds in the blood-brain and -testis barriers was investigated using Bcrp(-/-) mice. Tissue/plasma concentration ratios in the brain (K(p,brain)) and testis (K(p,testis)) obtained
Zhuomin Zhang et al.
The Analyst, 133(9), 1187-1194 (2008-08-19)
In competition sports, a diuretic is a substance widely prohibited by the World Anti-Doping Agency (WADA). In this paper, a sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS) and bumetanide (BUMET)] and basic [triamterene (TRIAM)]
Yiqun Wu et al.
Clinical drug investigation, 31(11), 769-777 (2011-06-16)
A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
Ali Asghar Ensafi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(11), 1449-1454 (2008-11-11)
A square-wave voltammetric procedure for the electroanalytical determination of losartan and triamterene in Britton-Robinson buffer (pH 3.0, 0.1 mol L(-1)) as a supporting electrolyte containing 30 ng mL(-1) of copper ions was developed. Opposite to the case of triamterene, losartan
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