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T3125

Sigma-Aldrich

Tetrahydrofolsäure

≥65% (when packaged), powder

Synonym(e):

5,6,7,8-Tetrahydropteroyl-L-glutaminsäure

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About This Item

Empirische Formel (Hill-System):
C19H23N7O6
CAS-Nummer:
135-16-0
Molekulargewicht:
445.43
Beilstein:
9238187
EG-Nummer:
205-181-1
MDL-Nummer:
MFCD00135583
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24900106
NACRES:
NA.51

Form

powder

Qualitätsniveau

200

Konzentration

≥65% (when packaged)

Farbe

faintly yellow to light brown

Lagertemp.

−20°C

SMILES String

NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1

InChI

1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChIKey

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

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Anwendung

Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches.
Tetrahydrofolic acid may also be used as a standard to generate calibration curve to quantify the folate types produced by Streptococcus thermophilus in milk cultures using high-performance liquid chromatography (HPLC). It is also suitable for use in the enzymatic assay of formate-tetrahydrofolate ligase from M. extorquens (MeFtfL).

Biochem./physiol. Wirkung

Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids

Verpackung

Verschweisste Ampulle

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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USP

USP

1286300

10-Formylfolsäure

Folsäure-(Glutaminsäure-13C5) ≥99 atom % 13C, ≥95% (CP)

Sigma-Aldrich

803049

Folsäure-(Glutaminsäure-13C5)

Dihydrofolate Reductase human ≥80% (SDS-PAGE), recombinant, expressed in E. coli, ≥1 units/mg protein

Sigma-Aldrich

D6566

Dihydrofolate Reductase human

DHFR from mouse recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sigma-Aldrich

SRP6119

DHFR from mouse

Folsäure British Pharmacopoeia (BP) Reference Standard

BP937

Folsäure

Folsäure BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sigma-Aldrich

F8758

Folsäure

Susanne H Kirsch et al.
Analytical and bioanalytical chemistry, 404(3), 895-902 (2012-06-26)
Folates act as essential coenzymes in many biological pathways, including the synthesis and methylation of DNA. Low folate concentration in serum and whole blood (WB) is associated with several disease conditions. We describe a stable-isotope-dilution ultra performance liquid chromatography tandem
Rima Obeid et al.
Metabolism: clinical and experimental, 60(5), 673-680 (2010-08-24)
Folate deficiency can cause age-related disease. Folic acid (FA) has been used in studies aiming at disease prevention. Recently, unmetabolized FA in plasma raised public health concerns; but numerous studies used FA for disease prevention. Concentrations of the folate forms
Lili Huang et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(36), 14801-14806 (2011-08-30)
Tetrahydrofolate (THF), a biologically active form of the vitamin folate (B(9)), is an essential cofactor in one-carbon transfer reactions. In bacteria, expression of folate-related genes is controlled by feedback modulation in response to specific binding of THF and related compounds
Tseng-Ting Kao et al.
International journal of food microbiology, 141(1-2), 17-27 (2010-05-21)
Staphylococcus aureus (S. aureus) is one of the most common pathogens that causes infectious and foodborne diseases worldwide. Searching for drug and chemical compounds against this bacterium is still in demand. We found that grape seed extract (GSE), a natural
Joseph R Graber et al.
Applied and environmental microbiology, 71(4), 1883-1889 (2005-04-07)
Treponema primitia, an H2-consuming CO2-reducing homoacetogenic spirochete in termite hindguts, requires an exogenous source of folate for growth. Tetrahydrofolate (THF) acts as a C1 carrier in CO2-reductive acetogenesis, a microbially mediated process important to the carbon and energy requirements of
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