T182

Tyrphostin A9

solid

• Synonym(e): Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
• Empirische Formel (Hill-System): C₁₈H₂₂N₂O
• CAS-Nummer: 10537-47-0
• Molekulargewicht: 282.38
• MDL-Nummer: MFCD00209853
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24278069
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: yellow
• mp (Schmelzpunkt): 139-140 °C
• Löslichkeit: ethanol: 20 mg/mL; DMSO: <25 mg/mL; H₂O: insoluble
• SMILES String: CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChIKey: MZOPWQKISXCCTP-UHFFFAOYSA-N
• Angaben zum Gen: human ... EGFR(1956) , ORAI1(84876) , PDGFRA(5156) , PDGFRB(5159) ; mouse ... Eef2k(13631) , Prkaca(18747) , Prkca(18750) , Src(20779)

Beschreibung

Anwendung

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Biochem./physiol. Wirkung

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

Leistungsmerkmale und Vorteile

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Angaben zur Herstellung

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301 + H311
• P-Sätze: P280 - P301 + P310 + P330 - P302 + P352 + P312
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges