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Wichtige Dokumente
T1452
TPCA-1
≥95% (HPLC)
Synonym(e):
[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide
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About This Item
Empirische Formel (Hill-System):
C12H10FN3O2S
CAS-Nummer:
Molekulargewicht:
279.29
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Assay
≥95% (HPLC)
Form
powder
Farbe
white to light brown
Löslichkeit
DMSO: 5 mg/mL, clear
Ersteller
GlaxoSmithKline
Lagertemp.
2-8°C
SMILES String
NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2
InChI
1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
InChIKey
SAYGKHKXGCPTLX-UHFFFAOYSA-N
Anwendung
TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.
Biochem./physiol. Wirkung
IKK-2 Inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.
Leistungsmerkmale und Vorteile
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Angaben zur Herstellung
TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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