T144

(±)-Thalidomid

≥98%, powder

• Synonym(e): 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindol-1,3(2H)-dion
• Empirische Formel (Hill-System): C₁₃H₁₀N₂O₄
• CAS-Nummer: 50-35-1
• Molekulargewicht: 258.23
• EG-Nummer: 200-031-1
• MDL-Nummer: MFCD00153873
• UNSPSC-Code: 12352111
• eCl@ss: 39180303
• PubChem Substanz-ID: 24278765
• NACRES: NA.77

Eigenschaften

• ligand: thalidomide
• Assay: ≥98%
• Form: powder
• Eignung der Reaktion: reagent type: ligand
• Farbe: white
• Löslichkeit: DMSO: 20 mg/mL, clear
• Ersteller: Celgene
• SMILES String: O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
• Angaben zum Gen: human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , LITAF(9516) , RBX1(9978) , TNF(7124) ; mouse ... Nos2(18126) ; rat ... Nos1(24598)

Beschreibung

Anwendung

Thalidomide has been used to study its neuropathological effects in mouse models of Alzheimer′s disease (AD). This study reported that long term administration of thalidomide causes beta-secretase inhibition and subsequently alleviates amyloid-like pathology. Furthermore, thalidomide has also been used to evaluate its teratogenic functions. Thalidomide was found to affect endodermal differentiation and neural development in differentiating human embryonic and induced pluripotent stem cells.

Biochem./physiol. Wirkung

(±)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). It also functions as an inhibitor of angiogenesis, an immunosuppressive agent, a sedative and a teratogen. Furthermore, thalidomide is known to exhibit antitumor functions in refractory multiple myeloma.

Leistungsmerkmale und Vorteile

This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Thalidomide is soluble in DMSO at a concentration that is more than 20 mg/ml. It is insoluble in water and ethanol.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H312,H360D
• P-Sätze: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Gefahreneinstufungen: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges