SRP8030

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

• Synonym(e): CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in HEK 293 cells
• Assay: >95% (SDS-PAGE)
• Form: lyophilized
• Mol-Gew.: ~35 kDa by SDS-PAGE
• Verpackung: pkg of 50 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: <0.1 EU/μg endotoxin, tested
• Farbe: white
• UniProt-Hinterlegungsnummer: Q9NP84
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... TNFRSF12A(51330)

Beschreibung

Allgemeine Beschreibung

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Physikalische Form

Lyophilized from PBS.

Rekonstituierung

Reconstitute with 50 μL deionized water.

Sonstige Hinweise

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable