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SRP6505

Sigma-Aldrich

G6PD human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(e):

Glucose-6-phosphate 1-dehydrogenase, Zwf

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About This Item

UNSPSC-Code:
12352204
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

Form

liquid

Mol-Gew.

61.4 kDa (515 aa, 1- 515 aa)

Verpackung

pkg of 100 μg

Konzentration

0.5 mg/mL

UniProt-Hinterlegungsnummer

P11413

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... G6PD(2539)

Allgemeine Beschreibung

G6PD (glucose-6-phosphate dehydrogenase) gene is mapped to human chromosome Xq28, and spans 16.2kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256Da. The active enzyme exists as a dimer, and contains an NADP molecule tightly bound to it.

Biochem./physiol. Wirkung

G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it is responsible for the oxidation of glucose-6-phosphate, and thus, confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogenous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.

Physikalische Form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 mM PMSF, 2 mM EDTA, 2 mM DTT, 200 mM NaCl.

Hinweis zur Analyse

The biological activity is > 7 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NAD or NADP. One unit oxidizes 1.0 μmole D-glucose-6-phosphate to 6-phospho-Dgluconate per min in the presence of beta-NADP at pH 7.4 at 25 °C.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H315,H319

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
7G27L75320
5C25L75320
5A02L75320

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Glucose-6-phosphat mol wt (glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2), pkg of 5 g

Roche

10127647001

Glucose-6-phosphat

Bilirubin ≥98% (EmM/453 = 60), powder

Sigma-Aldrich

B4126

Bilirubin

NADP Disodium salt

Roche

NADP-RO

NADP

Hämoglobin human lyophilized powder

Sigma-Aldrich

H7379

Hämoglobin human

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.
Manjurano A, et al.
PLoS Genetics, 11(2) (2015)
Glucose-6-phosphate dehydrogenase deficiency: a historical perspective.
Beutler E
Blood, 111(1), 16-24 (2008)
G6PD deficiency.
E Beutler
Blood, 84(11), 3613-3636 (1994-12-01)
Saúl Gómez-Manzo et al.
International journal of molecular sciences, 15(11), 21179-21201 (2014-11-20)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, causing a wide spectrum of conditions with severity classified from the mildest (Class IV) to the most severe (Class I). To correlate mutation sites in the G6PD with the
Yang Zhang et al.
Cell metabolism, 33(1), 94-109 (2020-11-08)
The emergence of cancer from diverse normal tissues has long been rationalized to represent a common set of fundamental processes. However, these processes are not fully defined. Here, we show that forced expression of glucose-6-phosphate dehydrogenase (G6PD) affords immortalized mouse
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