Direkt zum Inhalt
Merck
Alle Fotos(1)

Key Documents

SRP6368

Sigma-Aldrich

TREM2 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(e):

Trem2a, Trem2b, Trem2c, Triggering receptor expressed on myeloid cells 2

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352200
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

liquid

Mol-Gew.

20.4 kDa (181 aa, 19-161 aa + His Tag)

Verpackung

pkg of 50 μg

Konzentration

0.25 mg/mL

UniProt-Hinterlegungsnummer

Q9NZC2

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... TREM2(54209)

Allgemeine Beschreibung

TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physikalische Form

0.25 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Qian Zhai et al.
Anesthesiology, 127(1), 98-110 (2017-04-12)
Microglia can not only detrimentally augment secondary injury but also potentially promote recovery. However, the mechanism underlying the regulation of microglial phenotypes after stroke remains unclear. Mice were subjected to middle cerebral artery occlusion for 60 min. At 3 days
Hyuk Sung Kwon et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 73, 215-218 (2020-02-19)
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic
Francesca Cignarella et al.
Acta neuropathologica, 140(4), 513-534 (2020-08-11)
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.