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SRP5130

Sigma-Aldrich

SMAD1, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

BSP1, JV4-1, JV41, MADH1, MADR1

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About This Item

CAS-Nummer:
444952-89-0
UNSPSC-Code:
12352200
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Mol-Gew.

~83 kDa

NCBI-Hinterlegungsnummer

NM_005900

Anwendung(en)

cell analysis

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... SMAD1(4086)

Allgemeine Beschreibung

SMAD1 is a member of the SMAD family which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The actions of bone morphogenetic proteins (BMPs) are mediated by SMAD1 and SMAD1 can be phosphorylated and activated by the BMP receptor kinase. Phosphorylated SMAD1 forms a complex with SMAD4 that is important for its function in the transcription regulation. The SMAD1-SMAD4 complex is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. The formation of a complex between STAT3 and SMAD1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neuronal progenitors.

Physikalische Form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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P A Hoodless et al.
Cell, 85(4), 489-500 (1996-05-17)
Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and are required for signaling by the TGF beta superfamily have been poorly defined. The Drosophila gene Mothers against dpp (MAD) and the C. elegans sma genes are
K Nakashima et al.
Science (New York, N.Y.), 284(5413), 479-482 (1999-04-16)
The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal

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