SRP4915

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

• Synonym(e): OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥90% (HPLC); ≥90% (SDS-PAGE)
• Form: lyophilized powder
• Mol-Gew.: ~47.0 kDa
• Verpackung: pkg of 25 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: endotoxin, tested
• NCBI-Hinterlegungsnummer: Q8IW75
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... SPA12(145264)

Beschreibung

Allgemeine Beschreibung

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

Biochem./physiol. Wirkung

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

Physikalische Form

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

Rekonstituierung

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: nwg