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Key Documents

SRP3298

Sigma-Aldrich

BMP-4 mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(e):

BMP-2B, DVR4

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

mouse

Rekombinant

expressed in E. coli

Assay

≥98% (HPLC)
≥98% (SDS-PAGE)

Form

lyophilized

Wirksamkeit

5-15 ng/mL ED50

Mol-Gew.

23.8 kDa

Verpackung

pkg of 10 μg

Verunreinigungen

<0.1 EU/μg endotoxin, tested

UniProt-Hinterlegungsnummer

P21275

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

mouse ... BMP4(12159)

Verwandte Kategorien

Allgemeine Beschreibung

The gene BMP4 (bone morphogenetic protein 4) encodes a member of the TGFβ (transforming growth factor β) superfamily of intercellular signaling proteins. It is found to be expressed in the extraembryonic ectoderm and mesoderm. E. coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Anwendung

Bone morphogenetic protein 4 (BMP4) mouse has been used as an agonist for activin A receptor 1 (ALK2) receptors to test the effects of ALK2 activation in cell death.

Biochem./physiol. Wirkung

Bone morphogenetic protein 4 (BMP4) facilitates the the formation of allantois and primordial germ cell precursors in mouse embryo. It participates in hepatic specification in the early embryo. It is critical for the lens-inducing activity of optic vesicle in mouse embryo. BMP4 mediates atrioventricular septation of the mouse heart.

Physikalische Form

Lyophilized from 10 mM Citric Acid.

Rekonstituierung

Centrifuge the vial prior to opening. Reconstitute in 10 mM Citric Acid to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319,H335

Gefahreneinstufungen

Eye Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

BMP4 is essential for lens induction in the mouse embryo.
Furuta Y and Hogan BL
Genes & Development, 12, 3764-3775 (1998)
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA
Genes & Development, 13, 424-436 (1999)
Flavio H Beraldo et al.
Journal of neurochemistry, 145(1), 68-79 (2017-12-22)
Stress-inducible phosphoprotein 1 (STI1) acts as a neuroprotective factor in the ischemic brain and its levels are increased following ischemia. Previous work has suggested that some of these STI1 actions in a stroke model depend on the recruitment of bone
An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
Jiao K
Genes & Development, 17, 2362-2367 (2003)
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Gouon-Evans V
Nature Biotechnology, 24, 1402-1411 (2006)
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