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SRP6156

Sigma-Aldrich

BMP-4 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(e):

BMP-2B, Bone morphogenetic protein 2B, Bone morphogenetic protein 4

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

Form

lyophilized

Wirksamkeit

2-10 ng/mL

Mol-Gew.

34 kDa (homodimer, glycosylated.)

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Verunreinigungen

<1 EU/μg protein Endotoxin level (LAL test)

NCBI-Hinterlegungsnummer

P12644

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... BMP4(652)

Verwandte Kategorien

Allgemeine Beschreibung

BMP4 (bone morphogenetic protein 4), a member of the highly conserved BMP family, is a growth factor and a pro-inflammatory and pro-atherogenic cytokine. BMPs are part of the TGFβ (tumor growth factor) superfamily of proteins. BMP4 gene is localized to human chromosome 14q22-q23.

Biochem./physiol. Wirkung

BMP4 (bone morphogenetic protein 4) is involved in modulating cell development in a wide variety of cells. It promotes the proliferation and migration of hepatocellular carcinoma cells, and the multiplication of ALK3 (activin-like kinase)-positive cells in skeletal muscle. This protein prevents the proliferation of lung fibroblasts and induces their differentiation into myocytes. In Sertoli cells, it promotes DNA synthesis and hence, the proliferation of Sertoli cells through Smad1/5 (small mothers against decapentaplegic) and ID2/3 (DNA binding protein inhibitor) pathway, and aberration in BMP4 expression results in azoospermia. In human males, the serum levels of BMP4 is linked with coronary artery disease (CAD) severity. BMP4 is crucial for maintaining the self-renewal capacity of ES (embryonic stem) cells, and achieves so by inhibiting extracellular receptor kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways.

Physikalische Form

Lyophilized from a PBS solution.

Angaben zur Herstellung

Centrifuge the vial prior to opening.

Rekonstituierung

Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
8K146445

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Die Dokumentenbibliothek aufrufen

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA et al
Genes & Development, 13(4), 424-436 (1999)
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.
Qi X et al
Proceedings of the National Academy of Sciences of the USA, 101(16), 6027-6032 (2004)
Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity.
Park CS et al
Medicine, 94(3), e1530-e1530 (2015)
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
Weaver M et al
Development, 127(12), 2695-2704 (2000)
BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia.
Hai Y et al
Discovery Medicine, 19(105), 311-325 (2015)
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