SRP3208
IL-3 from mouse
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(e):
HCGF, MCGF (Mast cell growth factor), Multi-CSF, P-cell stimulation factor
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
mouse
Rekombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
Form
lyophilized
Wirksamkeit
≤0.05 ng/mL ED50
Mol-Gew.
15.1 kDa
Verpackung
pkg of 10 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<0.1 EU/μg endotoxin, tested
Farbe
white to off-white
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
mouse ... IL3(16187)
Allgemeine Beschreibung
IL-3 (interleukin 3) is primarily produced by activated CD4+ T cells and mast cells, and is a multi-lineage hematopoietic growth factor and immunoregulatory cytokine.
Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
Biochem./physiol. Wirkung
IL-3 (interleukin 3) plays a key role in the differentiation of murine hematopoietic progenitor cells and the activation and survival of mature myeloid cells. This protein was originally termed as multicolony-stimulating factor (multi-CSF) because of its capability to induce the differentiation of a wide variety of hematopoietic progenitor cells from bone marrow, such as mast cells, basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes. IL-3 promotes mast cell growth, differentiation, and mediator release, hence, suggesting a role in allergic inflammation. In mice, it is involved in suppressing protective immunity against Plasmodium berghei NK651, and prevents the development of splenomegaly, anemia, and erythropoiesis. It functions as a regulator of osteoclastogenesis, where it play a dual role- it facilitate the development of osteoclast progenitors but suppresses the osteoclastogenic process.
Sequenz
MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC
Physikalische Form
Lyophilized from 0.1% TFA.
Rekonstituierung
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Huixian Hong et al.
Biochemical and biophysical research communications, 440(4), 545-550 (2013-10-10)
Interleukin (IL)-3, a multilineage hematopoietic growth factor, is implicated in the regulation of osteoclastogenesis. However, the role of IL-3 in osteoclastogenesis remains controversial; whereas early studies showed that IL-3 stimulates osteoclastogenesis, recent investigations demonstrated that IL-3 inhibits osteoclast formation. The
Interleukin-3-deficient mice have increased resistance to blood-stage malaria.
Auclair SR et al
Infection and Immunity, 82(3), 1308-1314 (2014)
J N Ihle
Chemical immunology, 51, 65-106 (1992-01-01)
Considerable information has accumulated over the past several years relating to the biological activities of IL-3 which supports that concept that IL-3 has a unique capacity to support the proliferation and differentiation of a wide spectrum of hematopoietic cells. The
Nadja Bakocevic et al.
European journal of immunology, 44(6), 1823-1834 (2014-03-13)
Basophils, a rare leukocyte population in peripheral circulation, are conventionally identified as CD45(int) CD49b(+) FcεRI(+) cells. Here, we show that basophils from blood and several organs of naïve wild-type mice express CD41, the α subunit of α(IIb)β₃ integrin. CD41 expression
Serena De Vita et al.
PloS one, 9(5), e96209-e96209 (2014-05-03)
Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of
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