Direkt zum Inhalt
Merck
Alle Fotos(1)

Wichtige Dokumente

SRP2080

Sigma-Aldrich

BRCA1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonym(e):

BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RNF53

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352200
NACRES:
NA.26

Biologische Quelle

human

Rekombinant

expressed in insect cells

Assay

≥70% (SDS-PAGE)

Form

frozen liquid

Mol-Gew.

~209 kDa

Verpackung

pkg of 20 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

350 μg/mL

Farbe

clear
 colorless

NCBI-Hinterlegungsnummer

NM_007296

UniProt-Hinterlegungsnummer

P38398

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... BRCA1(672)

Biochem./physiol. Wirkung

The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks. Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer.

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Corinne Chabalier-Taste et al.
Oncotarget, 7(3), 2269-2283 (2016-01-09)
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles
E Maldonado et al.
Nature, 381(6577), 86-89 (1996-05-02)
We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators
R Scully et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(11), 5605-5610 (1997-05-27)
The familial breast-ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme over multiple chromatographic steps. Other tested transcription activators that
S K Sharan et al.
Nature, 386(6627), 804-810 (1997-04-24)
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.