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Key Documents

SRP0349

Sigma-Aldrich

Flt3 active human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonym(e):

CD135, FLK2, STK1, fms-related tyrosine kinase 3

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About This Item

CAS-Nummer:
1688608-05-0
UNSPSC-Code:
12352200
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in baculovirus infected Sf9 cells

Assay

≥80% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

54.2 kDa

Verpackung

pkg of 10 μg

Methode(n)

activity assay: suitable
inhibition assay: suitable

NCBI-Hinterlegungsnummer

NM_004119

UniProt-Hinterlegungsnummer

P36888

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... FLT3(2322)

Allgemeine Beschreibung

Human Flt3 (GenBank Accession No. NM_004119), amino acids 564-end with N-terminal His-tag, MW=54.2 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Anwendung

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360D

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Connor P Hall et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 22(3), 621-632 (2015-06-18)
The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). The cytotoxic effects of BEZ235 and dexamethasone as single
Mark Levis et al.
Blood, 106(2), 673-680 (2005-03-31)
Internal tandem duplication mutations of the FLT3 gene (FLT3/ITD mutations) are the most frequent molecular abnormality in acute myeloid leukemia (AML) and are associated with a poor overall survival. While the normal FLT3 receptor is expressed in early hematopoietic progenitor
Shinichiro Takahashi et al.
Leukemia research, 29(8), 893-899 (2005-06-28)
Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B
Amanda Lance et al.
Leukemia, 34(2), 369-379 (2019-08-30)
Three annotated CSF3R mRNA splice variants have been described. CSF3R-V1 is the wild-type receptor, while CSF3R-V4 is a truncated form increased in some patients with AML. CSF3R-V3 mRNA was identified in placenta more than 20 years ago, but remains largely
Hideki Nakano et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3808-3819 (2015-03-15)
Differential display of the integrins CD103 and CD11b are widely used to distinguish two major dendritic cell (DC) subsets in nonlymphoid tissues. CD103(+) DCs arise from FLT3-dependent DC precursors (preDCs), whereas CD11b(hi) DCs can arise either from preDCs or FLT3-independent
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