SML3236

UNC10201652

≥98 mg/mL (HPLC)

• Synonym(e): 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, 1,2,3,4-Tetrahydro-5-(4-morpholinyl)-8-(1-piperazinyl)[1,2,3]triazino[4′,5′:4,5]thieno[2,3-c]isoquinoline
• Empirische Formel (Hill-System): C₂₀H₂₅N₇OS
• CAS-Nummer: 372495-52-8
• Molekulargewicht: 411.52
• UNSPSC-Code: 12352107
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Konzentration: ≥98 mg/mL (HPLC)
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: C12=C(N3CCOCC3)N=C(SC4=C5N=NN=C4N6CCNCC6)C5=C1CCCC2
• InChIKey: ZPVQONCMKZBGTB-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

UNC10201652 is a potent and substrate-dependent slow-binding inhibitor of bacterial β-glucuronidases (GUSs) in the gut. UNC10201652 appears to target a catalytic intermediate. It alleviates irinotecan-induced gut damage in mouse models of cancer.

Biochem./physiol. Wirkung

potent and selective slow binding inhibitor microbiome β-glucuronidase enzyme

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable