SML3197

CA77.1

≥98% (HPLC)

• Synonym(e): N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide, N-[4-(6-Chloro-2-quinoxalinyl)phenyl]-acetamide
• Empirische Formel (Hill-System): C₁₆H₁₂ClN₃O
• CAS-Nummer: 2412270-22-3
• Molekulargewicht: 297.74
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: Clc1cc2ncc(nc2cc1)c3ccc(cc3)NC(=O)C
• InChI: 1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)
• InChIKey: ZQXMPDVGBWOTBY-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

CA77.1 is an orally available, brain penetrant, in vivo active and potent enhancer of chaperone-mediated autophagy (CMA). It improves pathology in Alzheimer′s Disease mouse models. CA77.1 activates CMA in vitro without affecting macroautophagy.

orally available, brain penetrant, in vivo active and potent enhancer of chaperone-mediated autophagy (CMA)

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable