SML3006

ICCB-19 Hydrochloride

≥98% (HPLC)

• Synonym(e): N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
• Empirische Formel (Hill-System): C₁₂H₂₁N₃OS · HCl
• CAS-Nummer: 1803605-68-6
• Molekulargewicht: 291.84
• MDL-Nummer: MFCD28145281
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C(NC1CCCCCC1)CSC2=NCCN2.Cl
• InChIKey: TZICOTBZKPHMMK-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable