SML2981

EN219

≥98% (HPLC)

• Synonym(e): 1-(3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone, 3,5-bis(4-Bromophenyl)-1-(chloroacetyl)-4,5-dihydro-1H-pyrazole
• Empirische Formel (Hill-System): C₁₇H₁₃Br₂ClN₂O
• CAS-Nummer: 380351-29-1
• Molekulargewicht: 456.56
• MDL-Nummer: MFCD02989881
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Brc1ccc(cc1)C2N(NC(=C2)c3ccc(cc3)Br)C(=O)CCl
• InChIKey: PREWPJFURADJST-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

EN219 is a cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 is shown to covalently interact with RNF114-C8 (IC50 = 470 nM), TUBB1-C201, HSPD1-C442, and HIST1H3A-C97. EN219 is a recruiter of the E3 ubiquitin ligase RNF114 that can be utilized for PROTAC applications.

cell-permeable chloroacetamide compound that selectively inhibits E3 ligase RNF114-mediated autoubiquitination and p21 ubiquitination

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable