SML1638

VX-745

≥98% (HPLC)

• Synonym(e): 5-(2,6-Dichlorophenyl)-2-(2,4-difluorophenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one
• Empirische Formel (Hill-System): C₁₉H₉Cl₂F₂N₃OS
• CAS-Nummer: 209410-46-8
• Molekulargewicht: 436.26
• MDL-Nummer: MFCD09834070
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825979
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: FC1=C(SC2=NN(C=N3)C(C=C2)=C(C4=C(Cl)C=CC=C4Cl)C3=O)C=CC(F)=C1
• InChI: 1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
• InChIKey: VEPKQEUBKLEPRA-UHFFFAOYSA-N
• Angaben zum Gen: human ... MAPK14(1432)

Beschreibung

Biochem./physiol. Wirkung

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα.

VX-745 is a selective blood-brain barrier penetrant inhibitor of p38 MAPKα. VX-745 showed 20-fold selectivity for p38α over p38β and a Ki value of 220 nM. VX-745 has been shown to reduce inflammation in an arthritic (AIA) mouse model and to improve performance in aged rats.

Sonstige Hinweise

VX-745 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the VX-745 probe summary on the Chemical Probes Portal website.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3