SML1523

Estetrol

≥98% (HPLC)

• Synonym(e): 15α-Hydroxyestriol, 3,15α,16α,17β-Tetrahydroxyestra-1,3,5(10)-triene, E4, Estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol, Oestetrol
• Empirische Formel (Hill-System): C₁₈H₂₄O₄
• CAS-Nummer: 15183-37-6
• Molekulargewicht: 304.38
• MDL-Nummer: MFCD00198996
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825940
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: [H][C@@]12CCC3=CC(O)=CC=C3[C@@]1([H])CC[C@@]4(C)[C@@]2([H])[C@@H](O)[C@@H](O)[C@@H]4O
• InChI: 1S/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/m1/s1
• InChIKey: AJIPIJNNOJSSQC-NYLIRDPKSA-N

Beschreibung

Allgemeine Beschreibung

Estetrol is an estrogenic steroid molecule produced exclusively during pregnancy by the fetal liver.

Biochem./physiol. Wirkung

Estetrol (E4, 15α-Hydroxyestriol) is an estrogen steroid hormone produced exclusively during pregnancy by the fetal liver. Estetrol is a selective estrogen receptor modulator (SERM) with potent estrogenic effects on vaginal mucosa, bone and brain, neutral effect on liver, and anti-estrogen effects on breast tissue. Estetrol has higher affinity for ERα over ERβ. Estetrol is being studied for its potential as a contraceptive, a drug for meopausal symptoms, and an anticancer agent.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable