E4876

17α-Ethinylestradiol

≥98%

• Synonym(e): 17α-Ethinyl-1,3,5(10)-oestratrien-3,17β-diol, 19-Nor-1,3,5(10),17α-pregnatrien-20-in-3,17-diol, Ethinyloestradiol
• Empirische Formel (Hill-System): C₂₀H₂₄O₂
• CAS-Nummer: 57-63-6
• Molekulargewicht: 296.40
• Beilstein: 2419975
• EG-Nummer: 200-342-2
• MDL-Nummer: MFCD00003690
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24894585
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Sterilität: non-sterile
• Assay: ≥98%
• Form: powder
• mp (Schmelzpunkt): 182-183 °C (lit.)
• Löslichkeit: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• Versandbedingung: ambient
• Lagertemp.: room temp
• SMILES String: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
• InChIKey: BFPYWIDHMRZLRN-SLHNCBLASA-N
• Angaben zum Gen: human ... ESR1(2099) ; rat ... Afp(24177) , Esr1(24890) , Shbg(24775)

Beschreibung

Allgemeine Beschreibung

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

Anwendung

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.

Biochem./physiol. Wirkung

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302,H351,H360Fd,H410
• P-Sätze: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges