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Key Documents

SML1455

Sigma-Aldrich

DAA-I acetate salt

≥98% (HPLC)

Synonym(e):

5-L-Isoleucine-2-10-Angiotensin I acetate salt, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu acetate, RVYIHPFHL acetate, [Des-Asp1-Ile5]angiotensin I, des-Asp-angiotensin I acetate, des-aspartate-angiotensin-I acetate

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About This Item

Empirische Formel (Hill-System):
C58H84N16O11 · xC2H4O2
CAS-Nummer:
56317-01-2
Molekulargewicht:
1181.39 (free base basis)
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

film

Farbe

colorless

Versandbedingung

wet ice

Lagertemp.

−20°C

Biochem./physiol. Wirkung

DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
Des-aspartate-angiotensin I (DAA-I) is a nine-amino acid angiotensin peptide and a metabolite of angiotensin DAA-I mediates attenuation of early inflammatory processes and intercellular adhesion molecule-1 (ICAM-1) formation in animal models.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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M Dharmani et al.
Regulatory peptides, 129(1-3), 213-219 (2005-06-02)
The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal
Ko-Onn Lee et al.
Drugs in R&D, 16(4), 317-326 (2016-09-30)
Des-aspartate-angiotensin I (DAA-I) is an endogenous angiotensin peptide and a prototype angiotensin receptor agonist (ARA). It acts on the angiotensin AT
Hong Wang et al.
PloS one, 10(9), e0138009-e0138009 (2015-09-18)
ACE inhibitors and ARBs (angiotensin receptor blockers) have been shown to attenuate radiation injuries in animal models of lethal gamma irradiation. These two classes of drug act by curtailing the actions of angiotensin II-linked inflammatory pathways that are up-regulated during
M R Mustafa et al.
Regulatory peptides, 120(1-3), 15-22 (2004-06-05)
An earlier study showed that des-aspartate-angiotensin I (DAA-I) attenuated the pressor action of angiotensin III in aortic rings of the spontaneously hypertensive rat (SHR) but not the normotensive Wistar Kyoto (WKY) rat. The present study investigated similar properties of DAA-I
Meng-Kwoon Sim et al.
Regulatory peptides, 188, 40-45 (2013-12-18)
L6 skeletal muscle cells overexpressed ICAM-1 when treated with H2O2. Maximum effect was observed at 200 μM H2O2. Des-aspartate-angiotensin I (DAA-I) concentration-dependently attenuated the overexpression. Maximum attenuation occurred at 10(-10) M DAA-I. H2O2 activated NFκB and its translocation into the
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