SML1311

Rubone

≥98% (HPLC)

• Synonym(e): (2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(2,4,5-trimethoxyphenyl)-2-propen-1-one, 2′-Hydroxy-2,4,4′,5,6′-pentamethoxychalcone
• Empirische Formel (Hill-System): C₂₀H₂₂O₇
• CAS-Nummer: 73694-15-2
• Molekulargewicht: 374.38
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: yellow to orange
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O(C)c1c(cc(c(c1)OC)\C=C\C(=O)c2c(cc(cc2O)OC)OC)OC
• InChI: 1S/C20H22O7/c1-23-13-9-15(22)20(19(10-13)27-5)14(21)7-6-12-8-17(25-3)18(26-4)11-16(12)24-2/h6-11,22H,1-5H3/b7-6+
• InChIKey: VHCQVGQULWFQTM-VOTSOKGWSA-N

Beschreibung

Biochem./physiol. Wirkung

Rubone has strong anticancer activity. Rubone and paclitaxel (PTX) combination therapy retarded cancer cell growth, migration and cancer stem-like cells (CSC) population growth.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells with wild-type or mutated p53. Rubone potently inhibits growth of hepatocellular carcinoma in a mouse xenograft model. Rubone does not effect the growth of nontumorigenic human hepatocytes.

Rubone is a miR34a modulator that specifically restores miR34a in hepatocellular carcinoma cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable