SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• Synonym(e): Geldanamycin, fluorescein isothiocyanate labeled
• Empirische Formel (Hill-System): C₅₅H₆₃N₅O₁₃S
• Molekulargewicht: 1034.18
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: Streptomyces hygroscopicus
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: yellow to yellow-orange
• Löslichkeit: DMSO: soluble 5 mg/mL
• Wirkungsspektrum von Antibiotika: neoplastics
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Chemical structure: benzenoid

Biochem./physiol. Wirkung

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable