SML0558

BETP

≥98% (HPLC)

• Synonym(e): 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine
• Empirische Formel (Hill-System): C₂₀H₁₇F₃N₂O₂S
• CAS-Nummer: 1371569-69-5
• Molekulargewicht: 406.42
• MDL-Nummer: MFCD23143626
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329825551
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: CCS(=O)c1nc(cc(n1)C(F)(F)F)-c2cccc(OCc3ccccc3)c2
• InChI: 1S/C20H17F3N2O2S/c1-2-28(26)19-24-17(12-18(25-19)20(21,22)23)15-9-6-10-16(11-15)27-13-14-7-4-3-5-8-14/h3-12H,2,13H2,1H3
• InChIKey: NTDFYGSSDDMNHI-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

BETP is a positive allosteric modulator of the GLP-1 receptor that potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cells, in the presence of the weak GLP-1 metabolite, GLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).

BetP is a trimeric Na⁺-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K⁺-concentration.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable