SML0436

BNS-22

≥98% (HPLC)

• Synonym(e): 8-[(3,4-Dihydro-2H-quinolin-1-yl)carbonyl]-5,7-dimethoxy-4-propyl-2H-chromen-2-one
• Empirische Formel (Hill-System): C₂₄H₂₅NO₅
• CAS-Nummer: 1151668-24-4
• Molekulargewicht: 407.46
• MDL-Nummer: MFCD22628799
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824719
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL (clear solution; warmed)
• Lagertemp.: 2-8°C
• SMILES String: COC1=C2C(OC(C=C2CCC)=O)=C(C(N3C(C=CC=C4)=C4CCC3)=O)C(OC)=C1
• InChI: 1S/C24H25NO5/c1-4-8-16-13-20(26)30-23-21(16)18(28-2)14-19(29-3)22(23)24(27)25-12-7-10-15-9-5-6-11-17(15)25/h5-6,9,11,13-14H,4,7-8,10,12H2,1-3H3
• InChIKey: LRPUQCTZOSTSGL-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

BNS-22 is a DNA-topoisomerase II (TOPO2) catalytic inhibitor.

BNS-22 is a derivative of natural product GUT-70 isolated from the stem bark of Calophyllum brasiliense exhibits antiproliferative activity against human cancer cells. It appears that BNS-22 is a specific DNA-topoisomerase II (TOPO2) catalytic inhibitor. BNS-22 does not induce DNA damage.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable