SML0350

AZD-7762 hydrochloride

≥98% (HPLC)

• Synonym(e): 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride
• Empirische Formel (Hill-System): C₁₇H₁₉FN₄O₂S · HCl
• CAS-Nummer: 1246094-78-9
• Molekulargewicht: 398.88
• MDL-Nummer: MFCD12546135
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825353
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to light brown
• Löslichkeit: DMSO: 15 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
• InChI: 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
• InChIKey: WFZBLOIXZRZEDG-YDALLXLXSA-N

Beschreibung

Anwendung

AZD-7762 hydrochloride has been used:

• as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines
• as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events
• as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development

Biochem./physiol. Wirkung

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H318
• P-Sätze: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable