SML0222

TVP1022

≥98% (HPLC)

• Synonym(e): (1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
• Empirische Formel (Hill-System): C₁₂H₁₃N
• CAS-Nummer: 185517-74-2
• Molekulargewicht: 171.24
• MDL-Nummer: MFCD09029306
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825241
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: DMSO: ≥15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: C#CCN[C@H]1CCc2ccccc12
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• InChIKey: RUOKEQAAGRXIBM-LBPRGKRZSA-N

Beschreibung

Biochem./physiol. Wirkung

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H400
• P-Sätze: P273 - P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable