SML0048

Salvianolsäure B

≥94% (HPLC)

• Synonym(e): (2S,3S)-4-[(1E)-3-[(1R)-1-Carboxy-2-(3,4-dihydroxyphenyl)-ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarbonsäure- 3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)-ethyl]-ester, Dan Shen Suan B, Danfensuan B, Lithospermic acid B
• Empirische Formel (Hill-System): C₃₆H₃₀O₁₆
• CAS-Nummer: 121521-90-2
• Molekulargewicht: 718.61
• MDL-Nummer: MFCD23115783
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 329825118
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥94% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +95 to +115°, c = 1 in methanol
• Farbe: white to tan
• Löslichkeit: H₂O: ≥5 mg/mL
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c3O[C@@H]([C@@H](C(=O)O[C@H](Cc4ccc(O)c(O)c4)C(O)=O)c23)c5ccc(O)c(O)c5
• InChI: 1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1
• InChIKey: SNKFFCBZYFGCQN-VWUOOIFGSA-N

Beschreibung

Anwendung

Salvianolic acid B (Sal B) has been used to determine the inhibitory effect of Sal B on aggregation kinetics of α-synuclein by thioflavin T (ThT) fluorescence assay. It has also been used as a reference compound to confirm the reproducibility of myelophil by finger printing analysis.

Salvianolic acid B has also been used to treat primary neuronal cells to test its effect on cell viability.

Biochem./physiol. Wirkung

Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease. Several mechanisms of action have been proposed including EGFR, PDGF and MMP-9 inhibition and inhibition of the TGF-β1/Smads and NF-κB signaling pathways. Salvianolic acid B acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable