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Merck

SAB5200074

Sigma-Aldrich

Monoclonal Anti-SCN2A1 antibody produced in mouse

clone S69-3, 1 mg/mL, purified immunoglobulin

Synonym(e):

Anti-NachII, Anti-Nav1.2, Anti-Nav1.2, S69-3, Anti-SCN, Anti-SCN2A, Anti-Scpll

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41
Konjugat:
unconjugated
application:
IHC
IP
WB
Klon:
S69-3, monoclonal
Speziesreaktivität:
human, rat, mouse
citations:
3
Methode(n):
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

S69-3, monoclonal

Form

buffered aqueous glycerol solution

Mol-Gew.

antigen predicted mol wt 250 kDa

Speziesreaktivität

human, rat, mouse

Konzentration

1 mg/mL

Methode(n)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG2a

NCBI-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

Verwandte Kategorien

Allgemeine Beschreibung

Sodium voltage-gated channel α subunit 2 (SCN2A1) is expressed in the axons and nerve terminals of the rat brain. The gene ID for the protein is 24766.

Spezifität

Detects ~250 kDa.

Immunogen

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2

Anwendung

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Monoclonal anti-SCN2A1 antibody produced in mouse has been used for immunofluorescence and Western blotting.

Biochem./physiol. Wirkung

Sodium voltage-gated channel α subunit 2 (SCN2A1) may associate with a number of other proteins in the rat brain. It regulates the conductance of action potentials and also controls the release of neurotransmitters.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

Lot/Batch Number

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Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Norelle C Wildburger et al.
Molecular & cellular proteomics : MCP, 14(5), 1288-1300 (2015-03-01)
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse
Je-Hyun Baek et al.
The Journal of biological chemistry, 289(22), 15363-15373 (2014-04-17)
Voltage-gated sodium (Nav) channels initiate action potentials in brain neurons and are primary therapeutic targets for anti-epileptic drugs controlling neuronal hyperexcitability in epilepsy. The molecular mechanisms underlying abnormal Nav channel expression, localization, and function during development of epilepsy are poorly
Jun Xiang et al.
Molecular medicine reports, 9(1), 16-22 (2013-11-14)
In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn

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