SAB4502369

Anti-HDAC8 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): FKSG78, G-protein coupled receptor 95, GPR87, GPR95, Probable G-protein coupled receptor 87
• MDL-Nummer: MFCD02686596
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 41 kDa
• Speziesreaktivität: human, rat, mouse
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: Q9BY41
• UniProt-Hinterlegungsnummer: Q9BY41
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HDAC8(55869)

Beschreibung

Allgemeine Beschreibung

Anti-HDAC8 Antibody detects endogenous levels of total HDAC8 protein.

The HDAC8 (histone deacetylase 8) gene is mapped to human chromosome Xq13.1. The encoded protein belongs to the class 1 histone deacetylase family.

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC8.

Immunogen Range: 5-54

Biochem./physiol. Wirkung

The HDAC8 (histone deacetylase 8) protein is significantly involved in cartilage development and matrix-specific gene transcription by catalyzing histone acetylation. HDAC8 has Zn²⁺-dependent hydrolase activity that deacetylates the acetyl lysine residues of both histone and non-histone proteins. Deacetylation of structural maintenance of chromosome protein 3(SMC3) by HDAC8 is necessary for recycling of cohesin complex during cell cycle. Mutation in the gene is observed in Cornelia de Lange syndrome which is characterised by mental retardation and facial deformity.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable