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Merck

SAB4501255

Sigma-Aldrich

Anti-LAMA1 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

LAMA, LAMA1, Laminin A chain, Laminin subunit α-1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 337 kDa

Speziesreaktivität

human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:40000
immunofluorescence: 1:100-1:500

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LAMA1(284217)

Allgemeine Beschreibung

Anti-LAMA1 Antibody detects endogenous levels of total LAMA1 protein.
Laminins are extracellular matrix proteins. The LAMA1 (laminin subunit α 1) gene is mapped to chromosome 18p11.

Immunogen

The antiserum was produced against synthesized peptide derived from human LAMA1.

Immunogen Range: 2501-2550

Anwendung

Anti-LAMA1, C-Terminal antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem./physiol. Wirkung

LAMA1 (laminin subunit α 1) participates in several diseases like cancer, infections, inflammatory diseases and autoimmune disorders. Mutations in LAMA1 result in cerebellar dysplasia and cysts with and without retinal dystrophy. LAMA1 is also essential in the assembly of basement membrane and early growth of embryo.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy
Aldinger KA, et al.
American Journal of Human Genetics, 95, 227-234 (2014)
?3 Chains of type V collagen regulate breast tumour growth via glypican-1
Huang G, et al.
Nature Communications, 8 (2017)
Vertebrate evolution by interspecific hybridisation--are we polyploid?
Spring J
Febs Letters, 400, 2-8 (1997)
Autoimmunity against laminins
Florea F, et al.
Clinical Immunology (Orlando, Fla.), 170, 39-52 (2016)
Guorui Huang et al.
Nature communications, 8, 14351-14351 (2017-01-20)
Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary

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