SAB4200623

Anti-C9orf72 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): 3110043O21Rik, AI840585, ALSFTD, C9orf72, FLJ11109, FTDALS, RGD1359108, RP23-307M2.1, zgc:100846
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Form: buffered aqueous solution
• Mol-Gew.: ~55 kDa
• Speziesreaktivität: human
• Konzentration: ~1 mg/mL
• Methode(n): immunoblotting: 0.3-0.6 μg/mL using whole extracts of T98G cells; immunocytochemistry: 4-6 μg/mL using SH-SY-5Y cells; immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon sections
• UniProt-Hinterlegungsnummer: Q96LT7
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... C9orf72(203228)

Beschreibung

Allgemeine Beschreibung

C9orf72 (chromosome 9 open reading frame 72) is a DENN domain containing protein. It is expressed in neuronal cell lines. It has been reported that C9orf72 colocalizes with Rab proteins, which indicates its role in autophagy and endocytic transport pathways.

Chromosome 9 open reading frame 72 (C9orf72) gene is mapped to human chromosome 9p21.

Spezifität

Anti-C9orf72 recognizes human C9orf72.

Immunogen

synthetic peptide corresponding to the N-terminal region of human C9orf72

Anwendung

Anti-C9orf72 antibody produced in rabbit may be used in:

• immunoblotting
• immunocytochemistry
• immunohistochemistry

Biochem./physiol. Wirkung

C9orf72 (chromosome 9 open reading frame 72) maintains a physical interaction with Rab proteins during autophagy, cellular trafficking and protein degradation. The cellular activities of the protein are not well defined. It has been reported that mutations of C9orf72 gene are associated with amyotrophic lateral sclerosis (ALS) with degeneration of upper and lower motor neurons in the brain, brainstem and spinal cord, leading to progressive paralysis and frontotemporal dementia.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Lagerung und Haltbarkeit

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable