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Merck

SAB4200181

Sigma-Aldrich

Anti-PMP70 antibody, Mouse monoclonal

enhanced validation

clone 70-18, purified from hybridoma cell culture

Synonym(e):

Anti- ZWS2; ZELLWEGER SYNDROME 2, Anti-70 kDa Peroxisomal membrane Protein, Anti-ABCD3, Anti-ATP-binding cassette, sub-family D (ALD), member 3, Anti-PXMP1

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

70-18, monoclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~70 kDa

Speziesreaktivität

rat, mouse, human

Verpackung

antibody small pack of 25 μL

Erweiterte Validierung

independent
Learn more about Antibody Enhanced Validation

Konzentration

~1.0 mg/mL

Methode(n)

immunofluorescence: suitable
western blot: 1-2 μg/mL using whole extracts of human HepG2 or rat PC12 cells

Isotyp

IgG1

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... ABCD3(5825)
mouse ... Abcd3(19299)
rat ... Abcd3(25270)

Allgemeine Beschreibung

Anti-PMP70 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma 70-18 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. The 70 kDa peroxisomal membrane protein (PMP70), also designated PXMP1 and ABCD3 or ABD3, is one of the major components of peroxisomal membranes. PMP70 belongs to the ALD subfamily of the ATP binding cassette (ABC) transporter superfamily. It is a half-size ABC integral membrane protein consisting of 6 transmembrane domains and one ATP-binding domain.

Anwendung

Anti-PMP70 antibody, Mouse monoclonal has been used in immunoblotting and immunofluorescence.

Biochem./physiol. Wirkung

The 70 kDa peroxisomal membrane protein (PMP70) participates in the metabolic transport of long and very long fatty acids into peroxisomes. It forms a stable complex with the adrenoleukodystrophy protein, adrenoleukodystrophy protein (ALDP), and several other peroxisomal proteins. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome-2, an autosomal recessive disorder that is manifested by defective import mechanisms for peroxisomal matrix enzymes.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern
Lombard-Platet G, et al.
Proceedings of the National Academy of Sciences of the USA, 93(3), 1265-1269 (1996)
Characterization of the 70-kDa peroxisomal membrane protein, an ATP binding cassette transporter
Imanaka T, et al.
The Journal of Biological Chemistry, 274(17), 11968-11976 (1999)
Jessica I Spiltoir et al.
ACS synthetic biology, 5(7), 554-560 (2015-10-30)
The blue-light-responsive LOV2 domain of Avena sativa phototropin1 (AsLOV2) has been used to regulate activity and binding of diverse protein targets with light. Here, we used AsLOV2 to photocage a peroxisomal targeting sequence, allowing light regulation of peroxisomal protein import.
A role for human N-alpha acetyltransferase 30 (Naa30) in maintaining mitochondrial integrity
Van DP, et al.
Molecular and Cellular Proteomics, 15(11), 3361-3372 (2016)
Fluorescent Tools to Analyze Peroxisome-Endoplasmic Reticulum Interactions in Mammalian Cells
Bishop A, et al.
Contact, 2, 2515256419848641-2515256419848641 (2019)

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