SAB3500496

Anti-SIRT5 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-NAD-dependent deacetylase sirtuin-5, Anti-SIR2L5, Anti-Sirtuin 5
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human, mouse
• Methode(n): indirect ELISA: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_036373
• UniProt-Hinterlegungsnummer: Q9NXA8
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SIRT5(23408)

Beschreibung

Allgemeine Beschreibung

SIRT5 (Sirtuin 5) is a mitochondrial matrix protein belonging to the class III of the sirtuin family. It is localized inside the mitochondria and within the cytosol and nucleus. The protein is widely expressed in the brain, heart, liver and kidney. It is composed of very short amino and carboxyl terminal sequences flanking region with the conserved, catalytic sirtuin center domain.

Immunogen

SIRT5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SIRT5.

Anwendung

Anti-SIRT5 antibody produced in chicken is suitable for western blot and indirect ELISA.

Biochem./physiol. Wirkung

SIRT5 (Sirtuin 5) is associated with metabolism and aging process. It has been reported in a study that SIRT5 influences urea cycle pathway by NAD-dependent deacetylation and subsequent activation of carbamoyl phosphate synthetase 1 (CPS1), which plays a vital role in the initial step of urea cycle for the detoxification and removal of ammonia. In non-small cell-lung cancer cells. SIRT5 contributions have also been observed for the cancer cell growth and drug resistance. Study shows that SIRT5 may possess oncogenic property.

Leistungsmerkmale und Vorteile

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Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500496.

Physikalische Form

Supplied in PBS with 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable