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Key Documents

SAB1300081

Sigma-Aldrich

Anti-LRP1 (C-term) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(e):

Anti-α-2-macroglobulin receptor, Anti-A2MR, Anti-Apolipoprotein E receptor, Anti-LRP, Anti-Low-density lipoprotein receptor-related protein 1

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.43

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Methode(n)

immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000

NCBI-Hinterlegungsnummer

NP_002323

UniProt-Hinterlegungsnummer

Q07954

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LRP1(4035)

Allgemeine Beschreibung

LRP1 (low density receptor protein 1) gene codes for a protein belonging to LDL receptor family. Lrp1 is known to be the largest mammalian endocytic receptor. The encoded protein is cysteine-rich and it is highly glycosylated. It is predominantly expressed in vascular smooth muscle cells, neurons, astrocytes, macrophages, hepatocytes, fibroblasts and malignant cells. The LDLRs (low-density lipoprotein receptors) have five domains namely repeated cysteine-rich regions of ligand-binding type and epidermal growth factor receptor-like repeats, YWTD (tyrosin, typrtophan, Threonine, aspartic) domains, a transmembrane domain, and a cytoplasmic tail that holds about three NPXY (asparagine-proline-X-tyrosine) motifs.

Immunogen

LRP1 (4520-4554)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP1.

Biochem./physiol. Wirkung

LRP1 functions as a scavenger by internalizing several plasma components and also serves as a signaling molecule. Lrp1 is responsible for the transport of β-amyloid (Aβ) across the blood brain barrier, thereby contributing to the pathogenesis of Alzheimer′s disease. Lrp1 is normally associated with the cell membrane, but proteolytic cleavage of the cell results in its soluble form. Therefore, it loses its ability to endocytose and transport ligands. LRP1 is associated with a number of signaling pathways, such as mitogen-activated protein kinase (MAPK), serine/threonine protein kinase (AKT), insulin receptor (IR), extracellular signal-regulated kinase (ERK), and c-jun N-terminal kinase (JNK) pathways.

Physikalische Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Joni M Prasad et al.
The Journal of biological chemistry, 291(35), 18430-18439 (2016-07-13)
The LDL receptor-related protein 1 (LRP1) is a large endocytic receptor that binds and mediates the endocytosis of numerous structurally diverse ligands. Currently, the basis for ligand recognition by LRP1 is not well understood. LRP1 requires a molecular chaperone, termed
Dong-Chuan Guo et al.
American journal of human genetics, 99(3), 762-769 (2016-08-30)
Acute aortic dissections are a preventable cause of sudden death if individuals at risk are identified and surgically repaired in a non-emergency setting. Although mutations in single genes can be used to identify at-risk individuals, the majority of dissection case
Patricia A Young et al.
The Journal of biological chemistry, 291(50), 26035-26044 (2016-10-31)
Hemophilia A is a bleeding disorder caused by a deficiency in coagulation factor VIII (fVIII) that affects 1 in 5,000 males. Current prophylactic replacement therapy, although effective, is difficult to maintain due to the cost and frequency of injections. Hepatic
B Shackleton et al.
Fluids and barriers of the CNS, 13(1), 14-14 (2016-08-10)
Transport across the blood-brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer's disease (AD). One of the receptors responsible for the transport of Aβ in the
Camilla De Nardis et al.
The Journal of biological chemistry, 292(3), 912-924 (2016-12-14)
LDL receptor-related protein 1 (LRP1) is a highly modular protein and the largest known mammalian endocytic receptor. LRP1 binds and internalizes many plasma components, playing multiple crucial roles as a scavenger and signaling molecule. One major challenge to studying LRP1
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