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S0439

Sigma-Aldrich

SUMO-1 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged)

Synonym(e):

Sentrin-1

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About This Item

MDL-Nummer:
MFCD03458656
UNSPSC-Code:
12352202
NACRES:
NA.32

Rekombinant

expressed in E. coli (GST-tagged)

Assay

≥95% (SDS-PAGE)

Mol-Gew.

38.5 kDa

UniProt-Hinterlegungsnummer

P63165

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... SUMO1(7341)

Allgemeine Beschreibung

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

Anwendung

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

Biochem./physiol. Wirkung

Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).
Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.

Physikalische Form

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish.
Yuan, et al.
Cell research, 20, 185-196 (2010)
J M Desterro et al.
Molecular cell, 2(2), 233-239 (1998-09-12)
Activation of NF-kappaB is achieved by ubiquitination and proteasome-mediated degradation of IkappaBalpha. We have detected modified IkappaBalpha, conjugated to the small ubiquitin-like protein SUMO-1, which is resistant to signal-induced degradation. In the presence of an E1 SUMO-1-activating enzyme, Ubch9 conjugated
J M Desterro et al.
FEBS letters, 417(3), 297-300 (1997-12-31)
Ubiquitin conjugating enzymes participate in the thioester cascade that leads to protein ubiquitination. Although Ubc9 is homologous to E2 ubiquitin conjugating enzymes we have shown that it is unable to form a thioester with ubiquitin, but can form a thioester
Masaki Akita et al.
Scientific reports, 5, 10984-10984 (2015-06-05)
The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the

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